Abstract:
1.1. Studies on total 5-hydroxytryptamine (5-HT) concentrations in tissues in rats infused with toxic doses of CaEDTA at 6 mmoles/kg per 24 hr, for 48 hr, indicate that appreciable alterations in tissue concentration of 5-HT do occur during chelate toxicity.2.2. The 5-HT concentrations in brain, duodenum and kidney of CaEDTA infused rats were significantly (P<0·05) lower than 5-HT concentrations in brain, duodenum and kidney of saline infused controls. No significant changes were observed in 5-HT concentrations in the liver of treated rats, compared to controls.