Nutripharmaceuticals and Local Pharmaceutical Excipients Research Group

Nutripharmaceuticals and Local Pharmaceutical Excipients Research Group

Focus: The aim of the research group is to facilitate the coordinated scale-up of key interventions through approaches such as preventive chemotherapy, curative chemotherapy, individual case management, vector control, veterinary public health and water, sanitation and hygiene (WASH). This vectors are normally the cause of tropical and neglected tropical diseases in West Africa and development of drug delivery materials (biomaterials, lipids) from indigenous plants with concomitant use of our local plants that are active against these diseases will be explored. The use of these herbs as nutrition through pharmaceutical formulations will be explored.

Base Department/Faculty: Pharmaceutics/Pharmaceutical Sciences

Description: Indigenous excipients are used in drug delivery owing to their biocompatibility, safe and biodegradable properties. The economic impact of tropical and neglected tropical diseases: generally, tropical and neglected diseases cost developing economies billions of dollars every year in lost revenue by interfering with labor productivity (agricultural and industrial) and with the wage-earning potential of individuals who are already poor and surviving on less than the US $ 2 a day. Herbal formulations will be used as nutritional remedy for some of these diseases.

Current research projects: Development of biomaterial and lipids for delivery of drugs for treatment of tropical and neglected diseases

Email: nutripharm@unn.edu.ng

Coordinator (name, department/academic unit, email and phone number):

Name: Dr John Dike Nwabueze OGBONNA,

Department: Pharmaceutics,

Email: john,ogbonna@unn,edu.ng

Phone number: +2348063674303

Members:

Dr John Dike N. OGBONNA

Prof Anthony A. Attama

Pharm. Adaeze C. Echezona-Nwosu

Pharm. Chinekwu S. Nwagwu

Pharm. Samuel W.  Uzondu

Mrs Chiamaka P. Uzoewulu

Areas of research interest:

Research interest is in biomaterial development, development of lipid from natural sources,

Contact details of coordinator:

Dr John Dike N. OGBONNA;  Email: john,ogbonna@unn,edu.ng   ,Phone number: +2348063674303

10 key publications:

  1. Nnamani P, Nnadi O,  Odo A, Abimbola V,  Ugwu A, Ibezim E, Ogbonna JD, Simon Onoja S,  Ayogu E, Adikwu M,  Lehr C-M,  Attama A. Gentamicin nanogel films based on Carrageenan-Prosopis africana for improved wound healing. Nanomed. 2022. 5(2):879-896.
  2. Ogbonna JDN, Cunha E, Attama AA, Ofokansi KC, Ferreira H, Pinto S, Gomes J, Marx ÍMG, Peres AM, Lobo JMS, ALmeida IF. Overcoming Challenges in Pediatric Formulation with a Patient‐Centric Design Approach: A Proof‐of‐Concept Study on the Design of an Oral Solution of a Bitter Drug. Pharmaceuticals 2022, 15, 1331. https://doi.org/10.3390/ph15111331
  3. Ogbonna JDN, Echezona AC, Nwagwu CS, Agbo CP, Onugwu AL, Kenechukwu FC, Akpa PA, Momoh MA, Attama AA. Formulation, in vitro and in vivo evaluation of sustained released artemether-lumefantrine-loaded microstructured solid lipid microparticles (SLMs). Trop J Nat Prod Res 2021; 5(8):1460-1469.
  4. Onugwu AL, Agbo CP, Nwagwu CS, Uzondu SE, Echezona AC, Ogbonna JDN, Kenechukwu FC, Umeyor CE, Uronnachi EM, Akpa PA, Momoh MA, Nnamani PO, Muller-Goymann CC, Attama AA. Development of lipid-based microsuspensions for improved ophthalmic delivery of gentamicin sulphate. Ther. Deliv. 2021; 10.4155/tde-2021-0039
  5. Nnamani PO, Echezona AC, Metu OC, Onoja SU, Ogbonna JDN, Akpa PA, Onunkwo GC, Nzekwe IT, Attama AA. Formulation and characterization of artemether-loaded sodium alginate microcapsules. Trop J Pharm Res. 2020; 19 (7): 1341-1349.
  6. Nwagwu CS, Ogbonna JDN, Nwobi LG, Echezona AC, Ugwu CN, Ezeibe EN, Ozioko AC, Nnamani PO, Attama AA. Design, development and evaluation of the repellent activity of Azadirachta Indica oil-based solid lipid microparticles against Aedes aegypti (Linn). Trop J Nat Prod Res 2020. 4(8):471-478.

 

  1. Echezona AC, Momoh MA, Akpa PA, Ogbonna JD, Reginald-Opara JN, Kenechukwu FC, Uzondu SW, Agbo CP, Ofokansi KC, Attama AA, Effect of molecular interaction on the antiplasmodial efficacy of lumefantrine in amorphous polymethacrylate-urea solid solution. J Drug Deliv Therap. 2020 10(5):56-69.
  2. Kenechukwu FC, Ofokansi KC, Momoh MA, Ogbonna JDN, Nnadi CO, Akpa PA. Solid Dispersions Based on Poloxamer 188 Improve the Dissolution Rate of Trandolapril, a Poorly Water-Soluble ACE Inhibitor. Ind J Novel Drug Deliv. 2017, 9(4) 254-263.
  3. Ogbonna JDN, Attama AA, Ofokansi KC, Patil SB, Basarkar GD. Optimization of formulation processes using Design Expert® Software for preparation of polymeric blends-artesunate-amodiaquine HCl microparticles. J Drug Deliv Sci Tech. 2017; 39: 36-49.
  4. Nnamani PO,Ugwu AA,Ibezim EC,Kenechukwu FC,Akpa PA,Ogbonna JDN, Obitte NC, Odo AN, Windbergs M, Lehr C-M, Attama AA. Sustained-release liquisolid compact tablets containing artemether–lumefantrine as alternate-day regimen for malaria treatment to improve patient compliance. Int J Nanomed 2016; 11: 6365–6378.