A complexation phenomenon between certain antimalarials (as donors) and chloranilic acid (as an acceptor) has been studied using thin-layer-chromatography (TLC). The antimalarials were subjected to charge–transfer complexation using chloranilic acid as the pi-acceptor. This technique was used for the qualitative detection of the drugs. Drug-spotted TLC plates, when developed in suitable solvent systems and sprayed with the pi-acceptor gave a spontaneous purple colour. The Rr values of the three drugs were found to be constant and specific for each drug sample in a particular solvent system.
Detection of halofantrine, mefloquine and proguanil thin layer plates by charge – Transfer complexation on. Available from: https://www.researchgate.net/publication/12487686_Detection_of_halofantrine_mefloquine_and_proguanil_thin_layer_plates_by_charge_-_Transfer_complexation_on [accessed Dec 28, 2015].