Contractile responses of uterine muscle strips to a saponin (DSS) isolated from the root of Dalbergia saxatilis was investigated in the rat. Uterine muscle response to the glycoside was characterized by a single but transient contraction that was concentration-dependent, with an ED50 of 0.13 mg/ml and 0.04 mg/ml as the lowest active concentration. Atropine sulphate (0.69 μmol) abolished uterine muscle responses induced by acetylcholine (1.82 μmol) but failed to block responses to submaximal concentration of DSS (0.24 mg/ml), suggesting that responses to DSS were not mediated by cell membrane cholinoceptor activation.
Fitoterapia 02/1999; 70(1):50-53. DOI:10.1016/S0367-326X(98)00019-7