Pre-clinical Research Group

Pre-clinical Research Group

 Focus: Offers laboratory-based drug screening and assay development to quickly identify drug candidates and targets for further development

 

COMPOSITION OF THE GROUP: The chairman of the PreClinical Research Group is Prof. Elvis Neba Shu (elvis.shu@unn.edu.ng; +234 803 317 0257) of the Department of Pharmacology & Therapeutics, College of Medicine. Prof Iroka J Udeinya (Department of Pharmacology & Therapeutics) and Dr Chukwugozie Okwuosa (Department of Medical Laboratory Sciences) are acting as vice-chairman and project manager, respectively. Other core members of the group are Dr Ignatius C. Maduka (Department of Chemical Pathology) and Mrs Akaniro-Ejim Nneoma E (Department of Pharmacology & Therapeutics).

PROPOSED RESEARCH ACTIVITIES:

  • Environmental Cynogenesis / Metallation.
  • Phyto-remediation of Polluted Industrial Effluent.
  • Waste to Wealth- the Nigeria Experience.
  • Air Quality studies.
  • Environmental Impact Assessment Studies.

 

 

 

Pre-clinical Research Group

 

Focus: Offers laboratory-based drug screening and assay development to quickly identify drug candidates and targets for further development

 

Coordinator: Prof. Elvis Neba Shu

 

Email: elvis.shu@unn.edu.ng      Phone: +234 803 317 0257

 


CURRICULUM VITAE

 

  1. NAME: Shu, Elvis Neba          2. SEX:                      Male
  2. DATE OF BIRTH: September 15, 1959   4. NATIONALITY: Cameroonian
  3. MARITAL STATUS: Married
  4. ADDRESS: Department of Pharmacology & Therapeutics, College of Medicine, University of Nigeria, Enugu Campus, PMB 01129 Enugu, Nigeria.

Mobile: +234 803 317 0257; e-mail: enshu1@yahoo.com; elvis.shu@unn.edu.ng

  1. DEGREES:
  2. MSc/Ph.D; Clinical Pharmacology; Department of Pharmacology & Therapeutics, College of Medicine, University of Nigeria, Enugu Campus, Enugu, Nigeria ( October 2000).
  3. M.Sc; Pharmacological Biochemistry; Nnamdi Azikiwe University, Awka, Nigeria (July 1992).
  4. Postgraduate Diploma; Pharmacological Biochemistry; Nnamdi Azikiwe University, Awka, Nigeria (August 1990).
  5. Diploma; Medical Laboratory Sciences; University of Yaounde, Cameroon (September 1983)

 

  1. POSTS HELD:
  2. —Professor of Pharmacology, Department of Pharmacology & Therapeutics, College of Medicine, University of Nigeria, Enugu Campus, Enugu, Nigeria (2009 till date).
  3. –Head, Department of Pharmacology & Therapeutics, College of Medicine, University of Nigeria, Enugu Campus, Enugu, Nigeria (2007 to 2010).
  4. —Senior Lecturer and Research Fellow, Department of Pharmacology & Therapeutics, College of Medicine, University of Nigeria, Enugu Campus, Enugu, Nigeria (2004 to 2009).
  5. –Lecturer 1, Department of Pharmacology & Therapeutics, College of Medicine, University of Nigeria, Enugu Campus, Enugu, Nigeria (2000 to 2004).
  6. –Grants Officer/Field Manager, Consortium for Health Research and Advanced Training (CHERAT), Faculty of Medical Sciences, University of Nigeria, Enugu Campus, Enugu, Nigeria (2004 till date).
  7. –Senior Research Fellow, Health Policy Research Group, College of Medicine, University of Nigeria, Enugu Campus, Enugu, Enugu State, Nigeria (2000 till date).
  8. –Consultant: Development of Health Master Plan for the Niger Delta States, Laye Medical Consultants LTD, Port Harcourt, February 2002 to December 2003.
  9. –Lecturer 1, Nnamdi Azikiwe University, Awka, Anambra State, Nigeria (1997 – 1999).
  10. –Assistant Lecturer, College of Medicine, Abia State University, Abia State, Nigeria (1994 – 1997).
  11. –Lecturer, Higher Training School for Health Personnel, Bamenda, Cameroon (1983-1986).

 

  1. SOME RESEARCH EXPERIENCE:
  2. 2012/2013: Co-PI in a study “Clinical Validation of a Urine Test for the Diagnosis of Malaria in Febrile Patients” sponsored by Fyodor Biotechnologies Inc, Baltimore, Maryland, USA
  3. 2011/2012: Co-Principal Investigator in a GSK/MVI-funded project “Consistency of immunogenicity and non-inferiority of three production lots of GSK Biological’s candidate malaria vaccine in children.”
  4. 2010/2012: Principal Investigator in a UK Department for International Development (DFID)-supported project (through Malaria Consortium) ‘An evaluation of sulphadoxine-pyrimethamine sensitivity and effectiveness of intermittent preventive treatment for malaria in pregnant women in Nigeria’.
  5. 2009/2010: Co-Investigator in a World Bank/STEP-B Research Grant ‘Seroepidemiological survey of Plasmodium falciparum strains in Southeastern Nigeria: A baseline study’.
  6. 2008/2009: Co-investigator in ‘An Equity and Cost-effectiveness Analysis of Alternative Strategies for the Deployment of Artemisinin-based Combination Therapy (ACT) at the Community Level’ (Malaria Consortium).
  7. 2008/2009: Principal Investigator in a Third World Academy of Science (TWAS)-funded project ‘Identification of new plant-based anti-malarial drugs with activities against adhesion of malaria-infected erythrocytes to target cells.’ ID No 07-128 LDC/BIO/AF/AC-UNESCO FR: 3240170576.
  8. 2008: Co-investigator in a Sanofi-funded project ‘Clinical evaluation of efficacy, tolerability and patient satisfaction of artesunate/amodiaquine (coarsucam(R)) for the treatment of uncomplicated malaria in daily practice in Nigeria’.
  9. 2007/2008: Evaluation of the efficacy and safety of artesunate-mefloquine (artequine paediatricR) in Nigerian children: a multicentre study.
  10. 2006/2008: Co-Principal Investigator in a WHO/MMV/GSK-supported Multi-centre, randomised, double-blind study to compare the safety, efficacy and pharmacokinetics of chlorproguanil HCl, dapsone and artesunate (CDA) versus artemether-lumefantrine (coartem) in the treatment of uncomplicated falciparum malaria in children and adolescents in Africa, Ref CDA 714703/005.
  11. 2007: Co-Principal Investigator in a Niemeth-funded project ‘Comparative efficacy and safety of artemeter-lumefantrine, artesunate plus amodiaquine and artesunate plus amodiaquine plus chlorpheniramine (artemcloTM) for acute uncomplicated malaria in Nigerian children’.
  12. 2005: Principal Investigator in a WHO-sponsored project “Inequities in access to interventions for malaria control in children under five years and pregnant women in southeast Nigeria” Ref TDR ID A50257.
  13. 2005: Co-Principal Investigator in a Pfizer-supported Multi-centre, randomised, double-blind study to compare the safety and efficacy of amodiaquine and sulphalene/pyrimethamine versus artemether-lumefantrine (coartem) in the treatment of uncomplicated falciparum malaria in children aged 6–120 months.
  14. 2004: Principal Investigator in an Alliance for Health Policy and Systems Research (AHPSR)-funded study on “Scaling-up of intermittent preventive treatment of malaria in pregnancy in southeast Nigeria: Biomedical and policy assessment” Ref: ID_3.070.
  15. 2003/2006: Co-Investigator in “Private and public providers of malaria treatment services in Anambra State, Nigeria: socio-economics of improving access to appropriate care” (Gates Malaria Partnership).
  16. 2002: Co-Investigator in an AHPSR-funded study on “Assessing the effects of different financing mechanisms on equity in access to and utilisation of primary health care services and developing a strategy for increasing the use of the services by the poor in Nigeria.”
  17. 2002: Co-Investigator in an IDRC-funded study on “Socio-economic differences in home-treatment of malaria and use of a novel community-based worker system to improve equitable access to appropriate treatment of malaria” (ID 20151).
  18. May, 2000: Co-Investigator in a WHO-sponsored project entitled “A comparative community-based

longitudinal study of socio-economic and biological components in mono-therapy versus combination

therapy for malaria in Nigeria,” TDR ID A00023.

  1. 1997/98: Co-Investigator in a WHO-sponsored project entitled “Economic cost and willingness to pay

for insecticide-treated nets and community financing of net re-impregnation, ” TDR ID 970320.

  1. 1996/97: Co-Investigator in a WHO-sponsored project entitled “Studies on the compliance of new packaging for chloroquine for home treatment of uncomplicated childhood malaria (TDR ID 960201)
  2. 1995/97: Co-Investigator in a WHO-sponsored project entitled “Community financing of onchocerciasis control using ivermectin in Nigeria: design, implementation, and evaluate a novel scheme,” TDR ID 950831.
  3. 1994/98: Principal Investigator in a WHO-sponsored project entitled “The use of school children in the promotion of compliance with malaria control and onchocerciasis chemotherapy,”TDR ID 940548
  4. 1992/94: Co-Investigator in an EEC-funded projects entitled Characterization and utilization of two new filarial models for investigation of immunity, chemotherapy and pathology (TS3.CT91-0037),
  5. 1989/1994: Co-Investigator in a WHO-sponsored project entitled Control of onchocerciasis in a rainforest-savannah mosaic area of South-Eastern Nigeria (ID 880218).

 

  1. SOME PUBLICATIONS
 

1. Mbah AU, Ghasi SI, Nweke IN, Obi EI, Anakwe RC, Ejim EC, Eze BI, Onodugo OD, Ndukwu GO, Ugwanna NC, Mbah JO, Shu EN and Okonkwo PO (2014). High salt-taste threshold is a good 10-year predictor of essential hypertension in a rural community cohort of young, adult and middle-aged Nigerians. Proceedings of the Nigerian Academy of Science (in press).

2. Tagbo Oguonu, Elvis N. Shu, Bertill U. Ezeonwu, Bao Lige, Anne Derrick, Rich E. Umeh and Eddy Agbo (2014). The performance evaluation of a urine malaria test (UMTTM) kit for the diagnosis of malaria in individuals with fever in south-east Nigeria: Cross-sectional analytical study. Malaria Journal 13: 403.

3. Ignatius C. Maduka, Francis C. Ezeonu, Emeka E, Neboh, Elvis N. Shu and Ebele J. Ikekpeazu (2014). Urinary bisphenol-A output in plastic industry workers: A possible indicator of occupational exposure. Tropical Journal of Medical Research 17 (2): 117- 120.

4. Rich Umeh, Stephen Oguche, Tagbo Oguonu, Simon Pitmang, Elvis Shu, Jude-Tony Onyia, Comfort A. Daniyam, David Shw, Abdullahi Ahmad, Erik Jongert, Grégory Catteau, Marc Lievens, Opokua Ofori-Anyinam, Amanda Leach (2014). Immunogenicity and safety of the candidate RTS,S/AS01 vaccine in young Nigerian children: a randomized, double-blind, lot-to-lot consistency trial. Vaccine 32 (48): 6556-6562.

5. Thomas Nubila, Ernest O. Ukaejiofo, Samuel O. Ike, Elvis N. Shu, Nkoyo I. Nubila, Chioli P. Chijioke, Ayodele C. Ukaejiofo, Eghosa E. Iyare, Chukwubuzor U. Okwosa and Oyinye V. Okwuowulu (2014). Predisposing factors associated with uncomplicated typr 2 diabetes among adults in a diabetic clinic, Enugu State, Nigeria. Transactions of the Royal Society of Tropical Medecine and Hygiene 108: 206-212.

6. Nubila T, Ukaejiofo EO, Nubila NI, Okwuosa CN, Chijioke CP, Shu EN and Iyare EE (2013). Sub-acute effects of crude methanolic leaf extract of Mucuna flagellipes (Vogel ex Hook) on haematological profile and haematinic activities in albino wistar rats. International Journal of Medicinal and Aromatic Plants 3 (4): 452-458.
  1. Nubila T, Ukaejiofo EO, Nubila NI, Iyare EE, Shu EN, Chijioke CP and Ibok IF (2013). Subacute effects of methanolic crude leaf extract of Gnetum africanum on the haematological profile in albino Wistar rats. International Journal of Medicinal and Aromatic Plants 3 (2): 220-225.
  2. Ohanu ME, Onuigbo H, Shu EN, and Okonkwo PO (2012). Efficacy of artemether in unresolving Plasmodium falciparum malaria. Nigerian Medical Practitioner 62 (5-6): 144-148.
  3. Miriam O. Aniagolu, Elvis N. Shu, Joel O. Onyeanusi, Emeka E. Neboh and Ebele J. Ikekpeazu (2012). Concentration-dependent effect of ivermectin on adenosine triphosphatase (ATPase) activities in human erythrocytes. Asian Journal of Medical Sciences 4 (2): 61-65.
  4. Augustine N. Odili, Birinus Ezeala-Adikaibe, Lutgarde Thijs, Samuel Kingue, Hilaire J Boombhi, Daniel Lemogoum, Joseph Kaptue, Marius Kamden, Jean-Bruno Mipinda,
    Babatunde A. Omotoso, Philip M. Kolo, Elvis N. Shu, Ademola Aderibigbe, Serigne A. Ba, Mouhamadou B. Ndiaye, Jan A. Staessen, Jean-René M’Buyamba-Kabangu. Benedict C. Anisiuba, Chinwuba K. Ijoma, Ifeoma I. Ulasi (2012). Progress Report on the first sub-Saharan trial of newer versus older antihypertensive drugs in native black patients. Trials 13: 59.
  5. Ogochokwu C. Onwujekwe, Rebecca O. Soremekun, Benjamein Uzochukwu, Elvis Shu, Obinna Onwujekwe (2012). Patterns of case management and chemoprevention for malaria-in-pregnancy by public and private sector health providers in Enugu State, Nigeria. BMC Research Notes 5: 211.
  6. Ignatius C. Maduka, Francis E. Ezeonu, Emeka E. Neboh, Elvis N. Shu, Ebele J. Ikekpeazu (2012). Urinary estrogen levels in women on contraceptives in Enug, South-East Nigeria. Journal of Family Medicine and Primary Care 1 (1): 39-42.
  7. Mbah AU, Ndukwu GO, Ghasi SI, Shu EN, Ozoemena FN, Mbah JO, Onodugo OD, Ejim EC, Eze MI, Nkwo PO, Okonkwo PO (2012). Low-dose lisinopril in normotensive men with idiopathic oligospermia and infertility: A 5-year randomised, controlled, crossover pilot study. Clinical Pharmacology and Therapeutics 91(4): 582-9.
  8. Maduka IC, Neboh EE, Shu EN, Ikekpeazu EJ (2010). Drug dosing in adult and paediatric population in developing countries: Possible pharmaceutical misadventure (A Review). British Journal of Pharmacology and Toxicology 1 (2): 77-80.
  9. Maduka Ignatius C, Ezeonu Francis C, Neboh Emeka E, Shu Elvis N, Ikekpeazu Ebele J. (2010): BPA and environmental estrogen in potable water sources in Enugu municipality, south-east Nigeria. Bulletin of Environmental Contamination and Toxicology 85 (5): 534-537.
  10. Maduka Ignatius C, Ezeonu Francis C, Neboh Emeka E, Shu Elvis E, (2010): Preponderance of bisphenol A in harvested rain water in Enugu municipality, South-East, Nigeria. Research Journal of Environmental and Earth Sciences 2 (1): 36-38.

 

 

CURRICULUM VITAE

Name:                                                  Iroka J. Udeinya

Place of Birth:                   Mgbowo, Awgu LGA, Enugu State

Education:

1963-1966.                          Our Lady’s High School, Onitsha,

West African Certificate, Division One (Distinction)

1973-1976.                          Brandeis University, Waltham, Massachussets, USA

B.A., Biology (major), Biochemistry (minor)

 

1976-1979.                          West Virginia University, Morgantown, West Virginia,

USA, Ph.D. Pharmacology

 

Chronology of Employment/Experience:

A). 1972-1973: Teacher, Government Secondary School, Dawakin Tofa, Kano State, Nigeria.

B). 1974-1976: Student Research Assistant, Brandeis University, Department of Biology.

C). 1975-1976: Student Independent Research (honors), Brandeis University. Department of

Biology.

D). 1976-1979: Graduate Student Research.West Virginia University. Department of                                                        Pharmacology

and Toxicology.

E). 1979-1983: Post-Doctoral Fellow. National Institutes of Health, Laboratory of Parasitic

Diseases.NIAID, Bethesda, Maryland, USA.

F). 1983-1987: Senior Lecturer/Consultant Pharmacologist. University of Nigeria, Nsukka.

College

of Medicine. Department of Pharmacology and Therapeutics.

G). 1988-1989: Senior Research Fellow. Walter Reed Army Institute of Research, Division of

Communicable Diseases and Immunology, Washington DC, USA.

H). 1989-1990: Adjunct Associate Professor of Pharmacology 1989, Research Professor of

                                Anesthesiology 1998. Howard University College of Medicine. Washington

DC

I). 2013-Date:   Professor (Contract). University of Nigeria, Nsukka. College of Medicine.

Department of Pharmacology and Therapeutics.

 

Competitive Research Grant Awards

 

A). 1980-1983: World Health        Organisation (WHO). Glycoprotein synthesis in the human malarial

parasite, Plasmodium falciparum

B). 1983-1984: WHO. Inhibition of cytoadherence to endothelial cells in vitro by immune serum from

adult Nigerians.

C). 1984-1985: WHO. To study the inhibition of endothelial cell and infected erythrocyte

Cytoadherence by immune serum, in acquired natural immunity in malaria.

D). 1986-1988: University Senate, UNN. To study the effect of local herbal preparation on the human

malarial Parasite in vitro.

 

E). 1993-1995: USAID. To study gestational malaria and the role of anti-adhesion antibody in

protective immunity to malaria.

F). 1996-1997: Fogarty Senior Research Scholar Award. To investigate adhesion reversal of P.

falciparum infected erythrocytes to endothelial cells.

 

Some Publications

Van Dyke, K., Van Dyke, C., Udeinya, I.J., Brister, C. and Wilson, M. 1979. a new screening system for non-steroid anti-inflammatory drugs based upon inhibition of chemiluminescence produced from human cells (graulocytes). Clin. Chem. 25: 1661-1665.

 

Udeinya, I. J. and Van Dyke, K. 1980. Labelling of membrane glycoproteins of cultivated Plasmodium falciparum. Bull. WHO 58: 445-448.

Epstein, N., Miller, L. H., Kaushal, D.C., Udeinya, I. J., Rener J., Howard, R. J., Asofsky, R., Aikawa, M., and Hess, R. L. 1981. Monoclonal antibodies against a specific surface determinant on malarial (plasmodium knowlesi) merozoites block erythrocyte invasion. J. Immunol. 127: 212-217.

 

Udeinya, I. J., and Van Dyke, K. 1981. concurrent inhibition by tunicamycin of glycosylation and parasitemia in malaria parasites P. falciparum cultured in human erythrocytes. Pharmacology 23: 165-170.

 

Udeinya, I. J., Schmidt, J., Aikawa, M., Miller, L. H. and Green, I. 1981. Falciparium malaria infected erythrocytes specifically bind to cultured endothelial cells. Science 213: (4507): 555-557

 

Udeinya, I. J., and Van Dyke, K. 1981. plasmodium falciparum: synthesis of glycoprotein by cultured erythrocyte stages. Exp. Parasitol. 52: 297.

 

Scmidt, J.A., Udeinya, I.J., Leech, J. H., Hay, R.A., Aikawa M., Barnwell, J., Green, I., and Miller, L. H. 1982. Plasmodium falciparum malaria. An amelanotic melanoma cell line bears receptors for the knob ligand on infected erythrocytes. J. Clin. Invest. 70: 379-382.

 

David, P. H., Hommel, M. Udeinya, I.J., and Miller, L. H. 1983. Parasite sequestration in Plasmodium falciparum malaria. Spleen and antibody modulation of cytoadherence by infected erythrocytes. Proc. Natl. Acad. Sci. USA. 80: 5075-5079.

 

Udeinya, I. J,. Miller, L. H., McGregor, I. A., and Jensen, J. B. 1983. Plasmodium falciparum strain-specific antibody blocks binding of infected erythrocytes to amelanotic melanoma cells. Nature 303: 429-431.

 

Aikawa M., Rabbege, J. R., Udeinya, I. J., and Miller, L. H 1983. Election microscopy of knobs in Plasmodium falciparum strain-specific antibody blocks binding of infected erythrocytes to amelanotic melanoma cells. J. Parasitol. (2) 69: 435-437

 

Udeinya, I. J., Graves, P. M., Carter, R., Aikawa, M., and Miller, L.H. 1983. Plasmodium falciparum: effect of time in continuous culture on binding to human endothelial cells and amelanotic melanoma cells. Exp. Parasitol. 56: 207-214.

 

Udeinya I. J., Leech, J., Aikawa, M., and Miller. L. H. 1985. An in vitro assay for sequestration: binding of Plasmodium falciparum infected erythrocytes to formalin fixed endothelial cells and amelonotic melanoma cells. J. Protozool. 3 (1): 88-90.

 

Udeinya, I. J., and Miller, L. H. 1987. Plasmodium falciparum: effect of infected erythrocytes on clotting time and plasma. Am. J. Trop. Med. And Hyg. 37 (2): 246-249.

 

Contreas, C.E., Santiago, J. I., Jensen, J. B., Udeinya, I. J., Biaoumi, I., Kennedy, D., and Tuilhe, T. 1988. RESA-IFA assay in Plasmodium falciparum malaria, observations on relationship between serum antibody titers, immunity and antigen diversity. J. Parasitol. 74 (1): 129-134.

 

Udeinya, I.J., Magowan, G., and Chulay, J. D. 1989. Long-Term cultured Human Vascular endothelial cells (EC-FP5) bind plasmodium falciparum infected erythrocytes. Am. J. Trop. Med. Hyg. 412 (4): 400-405.

 

Udeinya, I. J. 1990. In vitro and Ex-Vivo models of sequestration in P. falciparum infection Am. J. Trop. Med. Hyg. 43 (2 pt 2): 2-5

 

Udeinya, I. J., and Akogyeram, C.O. 1993. Induction of Endothelial adhesion by P. falciparum. Am. J. Trop. Med. Hyg. 48: 488-495.

Udeinya, I. J. 1993. Factors in endothelial proliferation and adhesivity. In Vitro cellular and developmental biology. 29A pp. 89-90.

 

Udeinya, I. J. 1993. Anti-malaria activity of Nigerian neem leaves. Trans. Soc. Trop. Med. Hyg. 87: 471

 

Udeinya, I. J., Mbah A. U., Chijioke, C.P. Shu E. N. An Antimalarial extract from neem leaves is antiretroviral. Trans Roy. Soc. Trop. Med. Hyg. (2004) 98, 435 – 437.

 

Udeinya, I J, Shu EN, Quakyi I, Ajayi FO (2006) An antimalarial neem leaf extract has both schizontocidal and gametocytocidal activities. American Journal of Therapeutics 15, 108-110, 2008

 

Mbah AU, Udeinya IJ, Shu EN, Chijioke CP, Offiah OC, Nubila T, Udeinya F, Mmuobieri A, Muobuike A and Obioma MS (2007). Fractionated neem leaf extract is safe ad increases CD4+ cell levels in HIV/AIDS patients. American Journal of Therapeutics; 14,369-374.

 

Udeinya JI, Shu EN, Quakyi I, Ajayi FO (2008). An antimalarial neem leaf extract has both schizontocidal and gametocytocidal activities. American Journal of Therapeutics 15 (2): 108-110.

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

CURRICULUM VITAE

NAME:                      Maduka               OTHER NAMES: Ignatius Chukwudi

DATE OF BIRTH:    31st July 1965     PLACE OF BIRTH: Onitsha

MARITAL STATUS: Married.                                

PERMANENT HOME ADDRESS:     Uruolu village, Akwaeze, Anaocha LGA, Anambra State

NATIONALITY:                                     Nigerian.

POSTAL ADDRESS                                                 School of Medical Laboratory Science, University of Nigeria

Teaching Hospital, Enugu, Nigeria

TELEPHONE NUMBER                       08033180616, 08095010693

E-MAIL ADDRESS                                 madukaig@yahoo.com

 

ACADEMIC RECORDS WITH DATES

  1. Medical Laboratory Science Council of Nigeria                           2011-2013
  2. Nnamdi Azikiwe University, Awka                                             2005-2010
  3. University of Nigeria, Enugu Campus                                         1997-2003
  4. University of Nigeria, Enugu Campus                                         1993-1996
  5. University of Nigeria Nsukka/School of Medical Laboratory

Sciences (SMLS), University of Nigeria Teaching Hospital

(UNTH), Enugu, Nigeria                                                              1986-1990

QUALIFICATIONS

1. Fellow, MLSCN                                                                         2013

2. Ph.D, Applied Biochemistry                                                       2010

  1. MSc, Clinical Chemistry                                                             2003
  2. PGD, Medical Laboratory Science (with Distinction)                 1996
  3. Associate, Medical Laboratory Science Council of Nigeria       1990

6. Fellow, Institute of Corporate Administration (FCAI)               2012

 

 

EMPLOYMENT HISTORY / PROFESSIONAL EXPERIENCE

 

  1. Deputy Director/ Head of School of Medical Laboratory

Science, U.N.T.H. Enugu                                                          2010- 2012

2. Part Time Lecturer, School of Medical Laboratory

     Sciences U.N.T.H. Enugu                                                           1996-2010

3. Medical Laboratory Scientist, University of Nigeria

     Teaching Hospital, Enugu, Nigeria                                           1993-2010

     a)   Chief Medical Laboratory Scientist                                     2009-2010

     b)   Assistant Chief Medical Laboratory Scientist                     2006-2009

     c)   Principal Medical Laboratory Scientist                               2002-2005

     d)   Senior Medical Laboratory Scientist                                   1999-2002

  1. e)   Medical Laboratory Scientist I                                            1996-1999

     f)   Medical Laboratory Scientist II                                             1993-1996

4. Laboratory Manager, Prestine Medical Laboratories

     Ltd, Onitsha, Nigeria                                                                   1992-1993

5. Medical Laboratory Scientist (youth Corper),

   Neuropsychiatric Hospital, Abeokuta, Nigeria.                             1991-1992

 

RESEARCH EXPERIENCE

  • PFIZER funded project titled, “Open label, randomized trial

comparing the efficacy and toleration of Sulphalene/Pyrimethamine plus Amodiaquine with Artemether plus Lumefantrine for the treatment of uncomplicated Plasmodium falciparium malaria”. July 2006 –December 2006.

 

  • WHO and GlaxoSmithkline Worldwide sponsored, “Multi-centre, randomized, double_blind, double dummy study comparing the efficacy and safety of Chlorproguanil-Dapsone-Artesunate versus Artemether-Lumefantrine in the treatment of acute uncomplicated Plasmodium falciparum malaria in children and adolescents in Africa”. January 2006 – August 2007.

 

  • Nigerian National Institute of Medical Research project, titled “Evaluation of the comparative efficacy and safety of Artemeter-Lumefantrine, Artesunate plus Amodiaquine and Artesunate plus Amodiaquine plus Chlorpheniramine (ARTEMOCLOTM) for acute uncomplicated malaria in Nigerian children. August 2007-December 2007.

 

  • MEPHA Ltd sponsored “Evaluation of the efficacy and safety of Artesunate and Mefloquine (Artequin-TM Paediatrique) in Nigerian Children: A multicentre study, March 2008-February 2009.

 

SOME RECENT PUBLICATIONS

   (1) Maduka IC, Ezeonu FC, Neboh EE, Shu EN and Ikekpeazu EJ (2014): Urinary bisphenol-A output in plastic industry workers: A possible indicator of occupational exposure. Tropical Journal of Medical        Research; 17 (2): 117-120

 

(2) Rasic-Milutinovic Z, Jovanovic D and Maduka IC (2014): Cadmium. In, Health Effects of Metals and Related Substances in Drinking Water: Research Report Series, Ferrante M, Conti GO, Rasic-Milutinovic Z and Jovanovic D, eds, IWA Publishing, UK; Pp 42-45

 

(3) Rasic-Milutinovic Z, Jovanovic D and Maduka IC (2014): Lead. In, Health Effects of Metals and Related Substances in Drinking Water: Research Report Series, Ferrante M, Conti GO, Rasic-Milutinovic Z and Jovanovic D, eds, IWA Publishing, UK; Pp 60-62

 

(4)   Mauceri C and Maduka IC (2014): Tin. In, Health Effects of Metals and Related Substances in Drinking Water: Research Report Series, Ferrante M, Conti GO, Rasic-Milutinovic Z and Jovanovic D, eds, IWA Publishing, UK; Pp 104-106

 

(5)   Duru R, Njoku O and Maduka I (2014): Oxidative stress indicators in patients with prostate disorders in Enugu, South-East, Nigeria. Biomed Res Int,10: 1155- 1161

 

(6)   Maduka IC, Ezeonu FE, Neboh EE, Shu EN and Ikekpeazu EJ (2012): Urinary estrogen levels in women on contraceptives in Enugu, South-East, Nigeria. J Fam Med Primary Care,1(1): 39-42.

 

(7) Maduka IC, Neboh EE, Ikekpeazu EJ, Okoro OI, Ufelle SA, and Onwusi EA (2012): Lead in potable water sources in Abakaliki metropolis, South-East, Nigeria. Bull Environ Contam Toxicol.; 88: 793- 796

 

(8)   Maduka IC, Ezeonu EF, Neboh EE, Shu EN and Ikekpeazu EJ (2010): BPA and Environmental Estrogen in Potable Water Sources in Enugu Municipality, South-East, Nigeria. Bulletin of Environmental Contamination and Toxicology; 85: 534-537

 

9) Maduka IC, Ezeonu FC, Neboh EE and Shu EN (2010): Preponderance of Bisphenol-A in Harvested Rain water in Enugu Municipality, South East, Nigeria. Research Journal of Environmental and Earth Sciences; 2(1):36-38

 

 

 

 

 

 

 

 

CURRICULUM   VITAE

NAME: Okwuosa, Chukwugozie Nwachukwu

DATE OF BIRTH: 20th October, 1970.

STATE OF ORIGIN: Anambra                         L.G.A: Idemili North

NATIONALITY: Nigerian.

MARITAL STATUS: Married.                        NO. OF CHILDREN: 2

        

EDUCATIONAL INSTITUTIONS ATTENDED WITH DATES:

  1. Ekulu Primary School, Enugu.——————————— 1975-1980
  2. I.C, Enugu—————————————————–1980-1985.
  3. University of Nigeria, Enugu Campus———————— 1986-1991.
  4. Nnamdi Azikiwe University, Nnewi Campus—————2000-2005
  5. University of Nigeria ——————————————-2011- ?

 

ACADEMIC QUALIFICATIONS OBTAINED:

  1. FSLC
  2. West African School Certificate/ General Certificate of Education.
  3. Bachelors degree in Medical Laboratory Sciences(B. MLS)
  4. Master of Science(M.Sc.) in Pharmacology and Toxicology
  5. D (In-View) in Pharmacology & Therapeutics

 

           WORKING EXPERIENCE

  1. Quality Control Analyst——–El-shaddai Pharmaceuticals Plc, Enugu
  2. Graduate Assistant, Dept of Med. Lab. Scs, University of Nigeria, Enugu Campus
  3. Senior Lecturer, Dept of Med. Lab. Scs, University of Nigeria, Enugu Campus——2012—till date.

 

SOME RECENT PUBLICATIONS

  1. Silas A Ufelle, Ernest O Ukaejiofo, Samuel I Ghasi, Chigozie N Okwuosa, Emeka E Neboh (2011): Myelo-protective activity of aqueous and methanolic leaf extracts of Vitex doniana in cyclophosphamide-induced myelo-suppression in wistar rats. Int J Biol Med Res. 2(1): 409-414

 

  1. Nwachukwu, DC.,Okwuosa, CN., Achukwu, PU., Azubike, NC and Eze, G (2011): Hepatoprotective activity of Methanol Extract of the Seeds of Sesamum indicum in carbon tetrachloride induced hepatoxicity in rats Indian Journal of Novel Drug Delivery 3(1): 36-42

 

  1. C.Azubike,P.U.Achukwu,C.N.Okwuosa, Y.Ajayi and A.C. Ugwu (2011): Extracts of Lawsonia inermis and Hibiscus sabdarriffa as Stains for Histological Sections J. Sci.Engr.Tech 18 (1): 9944-9952

 

  1. Okwuosa, C.N., Okoi-Ewa, R., Achukwu, P.U., Onuba, A.C., Azubuike, N.C (2011): Gastroprotective Effect of Crude Hexane Leaf Extracts of Sesamum indicum In Rabbits Nigerian Journal of Physiological Sciences 26: 049 – 054

 

  1. Theophilus K Udeani, Chukwugozie N Okwuosa, Ezinne U Adiele (2013): Effect of Aspergillus flavus on the Liver of Experimental Rats Administered with Antiretroviral Drugs American Journal of Phytomedicine and Clinical Therapeutics (6): 443 – 456 impact factor

 

  1. Achukwu PU, Ezeasor DN, Okwuosa CN, Azubike NC, Onwukwe OS (2012): Determination of levels of mercury contamination of water bodies in Enugu Metropolis and some major water bodies in south-East Nigeria Journal of Environmental Management and Safety 3(4):73-76

 

  1. NC Azubike, CN Okwuosa, OS Onwukwe, IC Anioke, OF Odo, J Ezugwu (2013): The sub-acute effect of exposure to smoke from Carica papaya leaves on the testis and brainof albino wistar rats J Sci Engr.Tech 20 (1): 11305-11313

 

  1. NC Azubike, CN Okwuosa, OS Onwukwe, SC Nnorom, OF Odo, IC Anioke, (2013): Effects of topical Herbal Medications on the Skin of Albino Wistar Rats Journal of Applied Sciences 16 (1): 10959-10965

 

  1. CN Okwuosa, NC Azubike, IC Anioke, AO Onyemelukwe, OS Onwukwe, C Eze (2013): Evaluation of the Biochemical and Toxicological Effect of the crude methanolic leaf extract of Momordica charantia in Rats Journal of Applied Sciences 16 (1): 10813-10824
  2. NC Azubike, CN Okwuosa, OS Onwukwe, AO Onyemelukwe, IC Anioke, DN Mbaukwu (2013): Common Errors detected on Prepared Slides For Histological Examination From Two Morbid Anatomy Laboratories in Enugu State. J Sci Engr.Tech 20 (1): 11348-11357
  3. CN Okwuosa, PUO Achukwu, NC Azubike, AIE Abbah (2012): Protective effect of the leaf extracts of Combretum racemosum on cyclophosphamide induced pancytopaenia and liver injury in male rats Research Journal of Pharmacology 6(2): 30-34 impact factor

 

  1. Onuh SN, Ukaejiofo, EO, Achukwu, PU, Ufelle, SA, Okwuosa, CN, Chukwuka CJ (2012): Haemopoietic activity and effect of crude fruit extract of Phoenix dactylifera on peripheral blood parameters Int J Biol Med. Res.3(2): 1720-1723

 

  1. Nwachukwu, DC and Okwuosa CN (2012): Investigation of the anti-ulcer activity of chloroform leaf extract of Aspilia afrricana in rats   Indian Journal of Novel Drug Delivery 4(1): 52-56

 

  1. Okwuosa CN, Nwachukwu Dc, Azubike NC (2012): Effect of Aspilia africana on Necrotizing Agent Induced Gastric Ulcer and Gastric Motility Indian Journal of Novel Drug Delivery 4(2): 110-114

 

  1. Achukwu PU, Azubike NC, Okwuosa CN, Onwukwe, OS (2011): Renoprotective effects of orally administered aqueous extract of Tridax procumbens on gentamicin induced nephrotoxicity in rats Journal of Experimental and Clinical Anatomy 9 (2): 47-52

 

  1. Theophilus K Udeani, Chukwugozie N Okwuosa, Ezinne U Adiele (2013): Effect of Aspergillus flavus on the Liver of Experimental Rats Administered with Antiretroviral Drugs American Journal of Phytomedicine and Clinical Therapeutics 1(6):443-456 impact factor

 

  1. Chukwugozie N Okwuosa, Theophilus K Udeani, Joshua E Umeifekwem, Augustine C Onuba, Innocent C Anioke and Romanus. E. Madubueze (2014): Hepatoprotective Effect of Methanolic Fruit Extracts of Phoenix dactylifera (Arecaceae) on Thioacetamide Induced Liver Damage in Rats American Journal of Phytomedicine and Clinical Therapeutics (2) (3): 290-300   impact factor

 

  1. Joshua Emeka Umeifekwem and Chukwugozie N Okwuosa (2014): Differential Effects of Two Modes of Exercise on Anthropometric Characteristics of Persons with Type-2 Diabetes Journal of Biology, Agriculture and Healthcare 4 (22)

 

  1. Otuu, Fred C.; Inya-Agha, Stella I.; Okwuosa, Chigozie N; Udeh, Clement M;Chukwu, Cecilia C; Ani, Godwin U (2014): Phytoremediation of Pharmaceutical effluent using n-Hexane de-fatted Moringa seed powder in Enugu State, South-Eastern Nigeria. International Journal of Research in Environmental Science and Technology 4(2): 39-43

 

  1. Okwuosa OM, Chukwura EI, Chukwuma GO, Okwuosa CN, Enweani IB, Agbakoba NR, Chukwuma CM, Manafa PO, Umedum CU (2012): Phytochemical and antifungal activities of Uvaria. chamae leaves and roots, Spondias mombin leaves and bark and Combretum racemosum leaves. African Journal of Medicine and Medical Science. Dec;41 Suppl:99-103. Impact factor

 

  1. Nubila T, Ukaejiofo, E O, Nubila, N I, Okwuosa CN, Chijioke CP, Shu E N, Iyare E E (2013): Sub-acute effects of crude methanolic leaf extracts of Mucuna flagellipes (Vogel ex Hook) on haematological profile and haematinic activities in albino wistar rats. International Journal of Medical and Aromatic Plants 3 (4): 452-458