Journal of Biologics Research and Development Vol.1 No. 1, March 2020
PRELIMINARY INVESTIGATION ON THE FUNCTIONAL PROPERTIES OF A NANOLIPOSOME FOR PARENTERAL DELIVERY OF ARTEMETHER LUMEFANTRINE
Onuigbo, E. Benedette*, Eze, C.Osita and Gugu, H. Thaddeus
Department of Pharmaceutical Microbiology and Biotechnology,
Faculty of Pharmaceutical Sciences, University of Nigeria, Nsukka, 410001, Enugu State, Nigeria
*For Correspondence: ebele.onuigbo@unn.edu.ng; Tel: +234-806-299-5712
ebele.onuigbo@unn.edu.ng
Journal of Biologics Research and Development Vol.1 No. 1, March 20202
ABSTRACT
Artemisinin have remained the stable drug of choice in the treatment of uncomplicated malaria. Unfortunately, it has poor aqueous solubility. This preliminary study seeks to investigate the functional properties of lumefantrine and artemether encapsulated in a nanoliposome for
parenteral administration. Nanoliposomes encapsulating artemether and lumefantrine were formulated through the Thin-Layer Evaporation method and evaluated for particle size, polydispersity index, encapsulation efficiency, and stability. The mean particle size of the empty nanoliposomes was 120.7 nm, while that of the drug-loaded carrier was 108.7 nm. The drugloaded liposome had a polydispersity index of 0.197, with the encapsulation efficiency of arthermether and lumefantrine being 79.4 % and 36.1 %, respectively. The liposomes showed good stability in the presence of increasing concentrations of Triton X-100. Overall, this study has shown that nanoliposomes have a great potential for possible use in the parenteral administration of artemether and lumefantrine.
Keywords: nanoliposomes, artemether, lumefantrine, stability, malaria
__________________________________________________________
EVALUATION OF SOME PROBIOTIC PROPERTIES OF LACTIC ACID BACTERIA ISOLATED FROM YOGHURT SAMPLES
CLICK TO DOWNLOAD JOURNAL
Enosakhare Oloton and Cynthia O. Nomamiukor
Department of Pharmaceutical Microbiology and Biotechnology. Faculty of Pharmacy. University of Benin.
For correspondence: Email: enosakhare.oloton@uniben.edu; Tel: +234-803-654-122
W A T
