The methanol and chloroform extracts of the root of Combretum dolichopetalum were obtained and gave yields of 6.48% w/w and 0.38% w/w respectively. The methanol extract significantly inhibited carageenin-induced mouse paw edema in a dose-dependent manner after an oral treatment. The maximum effect was achieved at a dose of 600 mg/kg and the result was comparable to that of indomethacin (10 mg/kg). The antiinflammatory activity of the chloroform extract against croton-oil induced mouse ear edema was significant (p < 0.001) and increased with the dose. The maximum effect (93%) was achieved with 1.0 mg of the extract per ear.
Phytomedicine 03/1998; 5(1):25-8. DOI:10.1016/S0944-7113(98)80055-X