Background: Use of PEP drugs is useful in preventing seroconversion following accidental occupational or nonoccupational exposures, thereby limiting further spread of HIV. Objective: This study aims to evaluate the clinicodemographic characteristics of patients accessing PEP services in a tertiary health institution. Study Design: This was a retrospective review of patients who obtained postexposure prophylaxis from the HIV clinic of a University Teaching Hospital in Nigeria. RESULTS: A total of 116 clients sought for PEP services during the study period. The commonest setting of exposure was needle injury (44.8%). Half of the clients presented within 24 hours following exposure. Being a male and knowing HIV status of source patient independently increased the likelihood of early presentation following exposure (P < .05). None of the patients that obtained the PEP drugs came for follow-up visits. Conclusion/Recommendation: Late presentation for PEP services following exposure means that more awareness needs to be created to facilitate early presentation.