Aflatoxins B2 (AFB2) and G2 (AFGZ) have been evaluated for activity toward the energy-linked reduction of endogenous nicotinamide nucleotides by succinate and vitamin K3 during anaerobic reversed electron transfer in isolated rat-liver mitochondria. These toxins induced a concentration-dependent biphasic inhibition involving three sites: suceinate dehydrogenase, adenosine triphosphatase and respiratory complex I. While AFB2 was more potent than AFG2. it appeared that inhibition did not result from facilitation of proton ionophoresis.
Food and Cosmetics Toxicology 11/1979; 17(5):501-4. DOI:10.1016/0015-6264(79)90010-5