Fast flow lactose (FFL) and anhydrous lactose (AHL) were comparatively investigated for the manufacture of pyridoxine hydrochloride tablets. The results showed that drug/FFL formulations possessed better performance. Harder tablets were, however, compressed from AHL blends. Linear relationships which correlate tablet physical properties to excipient concentration in a given formulation were established. Tablet batches formulated with FFL dissolved in shorter times und showed better stability characteristics on aging.
Pharmazie 04/1988; 43(3):188-90.